His 70 points eclipsed the franchise mark of 68 points, which had been held since 1967 by the great Wilt Chamberlain.
In addition, Embiid grabbed a career-high 18 rebounds and provided five assists.
“Anything can happen when he gets motivated like that,” 76ers head coach Nick Nurse said.
“He has a lot of ways to score. He gets a lot of things around the basket and a lot of free throws because of his sheer size.
“And his shooting touch is the skill that makes it extra hard to stop him.”
With 18 points, Tyrese Maxey was the next highest scoring player for the 76ers, while Victor Wembanyama, the first round pick overall, led the Spurs with 33 points.
The Spurs sit at the basement of the Western Conference with just eight wins from 43 games, while the 76ers, who have won three straight games, are third in the Eastern Conference.
A career-high 62 points were scored by Karl-Anthony Towns in the Minnesota Timberwolves’ 128-125 home loss to the Charlotte Hornets.
Two NBA players scoring at least 60 points on the same day happened just four times, and not since 1978.
They called a timeout to let Embiid, the NBA’s Most Valuable Player, depart the game after he shattered the 76ers record with one minute and forty-one seconds left. The Philadelphia Wells Fargo Center gave him a standing ovation.
The other players to score 70 points or more in a game are Damian Lillard, Devin Booker, Donovan Mitchell, Kobe Bryant, David Robinson, David Thompson, and Elgin Baylor.
With 100 points for the Philadelphia Warriors against the New York Knicks in 1962, Chamberlain maintains the record.
The game took place exactly eighteen years to the day after the legendary Kobe Bryant of the Los Angeles Lakers outscored the Toronto Raptors with 81 points, the second-highest individual total in NBA history.
“From the time I started playing, Kobe was my guy,” said Embiid.
“I started playing basketball because of him. It’s strange because he was my favorite player and scored 81 that same night.”
Embiid has now scored 30 points or more in 21 straight games.
With a career-high 43 points, Kevin Durant led the Phoenix Suns to a 115-113 victory over the Chicago Bulls at home.
With 31 points, 17 rebounds, and 10 assists, Giannis Antetokounmpo led the Milwaukee Bucks to their ninth straight victory against the Detroit Pistons, winning 122-113.
The Boston Celtics defeated the Dallas Mavericks 119-110 behind the 39 points and 11 rebounds of Jayson Tatum. Luka Doncic scored 33 points for the Mavericks.